Marcin Warmiński, PhD

Research interests

• Design and synthesis of chemically modified nucleotides and oligonucleotides as tools for studying the structure and function of nucleic acids and their complexes with proteins, as well as for obtaining molecules with potential therapeutic applications.
• Structural studies (X-ray crystallography, nuclear magnetic resonance spectroscopy) of natural and synthetic (oligo)nucleotide in complexes with proteins.

Education and professional experience

October 2021 – now	Assistant professor at Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw;
October 2019 – September 2021	Assistant at Divition of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw;
June 2019	Ph.D. in Biophysics, Faculty of Physics UW: Design and synthesis of molecular tools for structural and functional investigation of mRNA 5’ end (cap) and studies on their complexes with proteins by X-Ray crystallography; Supervisor: Prof. Jacek Jemielity;
May 2018 – September 2018	Internship in Prof. John D. Gross’s laboratory at the University of California, San Francisco (UCSF);
May 2015 – July 2015	Internship in Prof. Marcin Nowotny’s Laboratory of Protein Structure at the International Institute of Molcular and Cell Biology (IIMCB) in Warsaw;
June 2013	M.Sc. in Chemistry (organic chemistry) at Faculty of Chemistry, University of Warsaw: Synthesis, properties, and applications of dinucleotide analogues of mRNA 5' end containing diamine linkers attached via a carbamate group to the ribose residue; Supervisor: Jacek Jemielity;
July 2012	B.Sc. in Chemistry (organic chemistry) at Faculty of Chemistry, University of Warsaw: Thiophosphate dinucleotide analogues of mRNA 5' end containing an isopropylidene modification in the ribose residue of 7-methylguanosine; Supervisor: Jacek Jemielity;
August 2009	Internship in Prof. Jadwiga Frelek’s laboratory at Institute of Organic Chemistry, Polish Acedemy of Science;

Research projects

• 2023 – 2026 „Modified (oligo)nucleotides for photo-controlled manipulation of mRNA” – SONATA project (National Science Centre Poland, 2022/47/D/ST4/00386). Project leader;
• 2013 – 2017 „Structural studies on mRNA 5' end analogues modified in the triphosphate bridge and their complexes with proteins as a step in the rational design of therapeutics and tools for molecular biology” – Diamentowy Grant project (Ministry of Science and Higher Education, DI2012 024842). Project leader;

Participation in research projects

• 2022 – 2027 „Horizon for Excellence in messenger RNA applications in immunoOncology [HERO]” – Wirtual Research Institute (Polish Science Fund, Łukasiewicz Research Network, Polish Center for Technology Development [PORT]).

Selected publications

All publication can be found at Google Scholar profile or ORCID

• “Chemical circularization of in vitro transcribed RNA for exploring circular mRNA design” Malgorzata Wasinska-Kalwa, Adam Mamot, Karol Czubak, Katarzyna Frankowska, Adam Ado Rajkiewicz, Tomasz Spiewla, Marcin Warminski, Zofia Pilch, Marta Szulc-Gasiorowska, Kacper Siekan, Andrzej Dziembowski, Dominika Nowis, Jakub Golab, Joanna Kowalska, Jacek Jemielity, Nature Communications 2025, 16(1): 6455; 10.1038/s41467-025-61775-1
• “An MST-based assay reveals new binding preferences of IFIT1 for canonically and noncanonically capped RNAs” Tomasz Spiewla, Katarzyna Grab, Anais Depaix, Kamil Ziemkiewicz, Marcin Warminski, Jacek Jemielity, Joanna Kowalska, RNA 2025, 31(2): 181–192; 10.1261/rna.080089.124
• “Structural basis of Spliced Leader RNA recognition by the Trypanosoma brucei cap-binding complex” Harald Bernhard, Hana Petržílková, Barbora Popelářová, Kamil Ziemkiewicz, Karolina Bartosik, Marcin Warmiński, Laura Tengo, Henri Gröger, Luciano G Dolce, Cameron D Mackereth, Ronald Micura, Jacek Jemielity, Eva Kowalinski, Nature Communications 2025, 16(1): 685; doi: 10.1038/s41467-024-55373-w
• “Proximity-induced SuFEx increases the potency of cytosolic nucleotidase inhibitors and reveals a rare example of covalently targeted histidine” Mikolaj Chrominski, Marcin Warminski, Mateusz Kozarski, Dorota Kubacka, Joanna Panecka-Hofman, Tomasz Spiewla, Mikolaj Zmudzinski, Jacek Jemielity, Joanna Kowalska, RSC Chemical Biology 2025, 6(6): 942–947; 10.1039/D5CB00005J
• “Aptamer-based assay for high-throughput substrate profiling of RNA decapping enzymes” Katarzyna Grab, Mateusz Fido, Tomasz Spiewla, Marcin Warminski, Jacek Jemielity, Joanna Kowalska, Nucleic Acids Research 2024, 52(21): e100; 10.1093/nar/gkae919
• “Trinucleotide cap analogs with triphosphate chain modifications: synthesis, properties, and evaluation as mRNA capping reagents” Marcin Warminski, Anais Depaix, Kamil Ziemkiewicz, Tomasz Spiewla, Joanna Zuberek, Karolina Drazkowska, Hanna Kedzierska, Agnieszka Popielec, Marek R Baranowski, Marta Sklucka, Marcelina Bednarczyk, Miroslaw Smietanski, Karol Wolosewicz, Bartosz Majewski, Remigiusz A Serwa, Dominika Nowis, Jakub Golab, Joanna Kowalska, Jacek Jemielity, Nucleic Acids Research 2024, 52(18): 10788–10809; 10.1093/nar/gkae763
• “Photoactivatable mRNA 5′ Cap Analogs for RNA-Protein Crosslinking” Marcin Warminski*, Katarzyna Grab, Kacper Szczepanski, Tomasz Spiewla, Joanna Zuberek, Joanna Kowalska, Jacek Jemielity, Advanced Science 2024, 11(36): 2400994; 10.1002/advs.202400994
• “Trinucleotide mRNA Cap Analogue N6-Benzylated at the Site of Posttranscriptional m6Am Mark Facilitates mRNA Purification and Confers Superior Translational Properties In Vitro and In Vivo” Marcin Warminski, Edyta Trepkowska, Miroslaw Smietanski, Pawel J. Sikorski, Marek R. Baranowski, Marcelina Bednarczyk, Hanna Kedzierska, Bartosz Majewski, Adam Mamot, Diana Papiernik, Agnieszka Popielec, Remigiusz A. Serwa, Brittany A. Shimanski, Piotr Sklepkiewicz, Marta Sklucka, Olga Sokolowska, Tomasz Spiewla, Diana Toczydlowska-Socha, Zofia Warminska, Karol Wolosewicz, Joanna Zuberek, Jeffrey S. Mugridge, Dominika Nowis, Jakub Golab, Jacek Jemielity, Joanna Kowalska, Journal of the American Chemical Society 2024, 146(12): 8149–8163; 10.1021/jacs.3c12629
• “Chemical modifications of mRNA ends for therapeutic applications” Marcin Warminski, Adam Mamot, Anaïs Depaix, Joanna Kowalska, Jacek Jemielity, Accounts of Chemical Research 2023, 56(20): 2814–2826; 10.1021/acs.accounts.3c00442

Patents and patent applications

• „Phosphorothiolate mRNA 5′-end (cap) analogs, mRNA comprising the same, method of obtaining and uses thereof” Jemielity J., Fac-Dąbrowska K., Wojtczak B., Baranowski M., Nowicka A., Kowalska J., Sikorski P., Warmiński M.; WO/2017/130151
• “Novel mRNA 5'-end cap analogs modified within phosphate residues. RNA molecule incorporating the same, uses thereof and method of synthesizing RNA molecule or peptide" Warminski M., Sikorski P., Kowalska J., Jemielity J.; PCT/PL2021/050006; WO/2021/162566
• „Novel mRNA 5'-end cap analogs, RNA molecule incorporating the same, uses thereof and method of synthesizing RNA molecule or peptide” Warminski M., Sikorski P., Kowalska J., Jemielity J.; PCT/PL2021/050007; WO/2021/162567
• „Circular RNA analogs comprising 7-methylguanosine cap, preparation, and application thereof” Mamot A., Wąsińska-Kałwa M., Frankowska K., Czubak K., Warmiński M., Kowalska J., Jemielity J., Nowis D., Gołąb J.; PCT/EP2024/063844
• „Dinucleotide monophosphate derivative, the nucleic acid derivative containing it, and the method of obtaining it” Perzanowska O., Kowalska J., Jemielity J. Mroczek S., Krawczyk P., Dziembowski A., Rajkiewicz A., Warmiński M., Grab K.; PCT/PL2024/050060

Awards and distinctions

• Scholarship of the Minister of Science and Higher Education for outstanding young scientists (2025);
• Distinction of the Rector of the University of Warsaw for scientific achievements (2025);
• Laureate of the START scholarship organized by the Foundation for Polish Science (2018);
• Laureate of the ETIUDA 5 scholarship organized by the National Science Centre (2017): “Design and synthesis of molecular tools for studying the structure and function of mRNA 5' end (cap) and studying their complexes with proteins using X-ray crystallography”;
• Winner of the Polish Chemistry Olympiad and silver medalist of the International Chemistry Olympiad (2009).